– Pharmacodynamic profile of GRX-917 indicates potential for anxiolytic activity without the significant sedative side effects associated with benzodiazepines
NEW YORK and BERLIN, April 28, 2023 (GLOBE NEWSWIRE) — atai Life Sciences (NASDAQ: ATAI) (“atai”), a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders, announced that pharmacodynamic data on GRX-917, a deuterated version of etifoxine, was selected for poster presentation and presented yesterday at the Society for Biological Psychiatry (SOBP) Annual Meeting. The SOBP annual meeting is being held in San Diego from April 27–29.
Late Breaking Poster Presentation Details:
Title: Pharmacodynamic Profile of GRX-917 Using Quantitative EEG in a Phase 1 Study
Poster Number: T46
Session Title: Poster Session I
Session Date & Time: Thursday, April 27th 5:30pm – 7:30pm PT
The analyses in the poster presentation are focused on the pharmacodynamic profile of GRX-917 and are based on the biomarker data from the completed Phase 1 study. As measured by EEG, GRX-917 demonstrated a statistically significant increase in beta power, a marker of potential anxiolytic effects, and which is similar to what is seen with exogenous neurosteroids and benzodiazepines. Unlike benzodiazepines, however, GRX-917 was found to not reduce alpha power, the decrease of which is associated with potential sedative effects. In the Phase 1 study, GRX-917 was safe and well-tolerated, with sedation comparable to placebo and consistent with the EEG results on alpha power.
The poster will be made available on the atai Life Sciences website at https://ir.atai.life/news-events/events.
About atai Life Sciences
atai Life Sciences is a clinical-stage biopharmaceutical company aiming to transform the treatment of mental health disorders. Founded in 2018 as a response to the significant unmet need and lack of innovation in the mental health treatment landscape, atai is dedicated to acquiring, incubating, and efficiently developing innovative therapeutics to treat depression, anxiety, addiction, and other mental health disorders.
By pooling resources and best practices, atai aims to responsibly accelerate the development of new medicines across its companies to achieve clinically meaningful and sustained behavioral change in mental health patients.
atai’s vision is to heal mental health disorders so that everyone, everywhere can live a more fulfilled life. For more information, please visit www.atai.life.
Forward Looking Statements
This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. We intend such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 27A of the Securities Act of 1933, as amended (the “Securities Act”), and Section 21E of the Securities Exchange Act of 1934, as amended (the “Exchange Act”). All statements contained in this press release and the accompanying presentation other than statements of historical fact should be considered forward-looking statements, including without limitation statements regarding the success, cost, and timing of development and potential of GRX-917 and related studies; our business strategy and plans, including potential partnerships and other strategic arrangements; and the plans and objectives of management for future operations and capital expenditures.
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